You are viewing a version of a model that has been updated. To access the latest version, and a more detailed display please go here.

DDMODEL00000132: Minimal model

  public model
Short description:
Minimal model of glucose kinetics and insulin action
PharmML (0.6.1)
  • Quantitative estimation of insulin sensitivity.
  • Bergman RN, Ider YZ, Bowden CR, Cobelli C
  • The American journal of physiology, 6/1979, Volume 236, Issue 6, pages: E667-77
  • Northwestern University Technological Institute, Illinois
  • We have evaluated the feasibility of using a mathematical model of glucose disappearance to estimate insulin sensitivity. Glucose was injected into conscious dogs at 100, 200, or 300 mg/kg. The measured time course of insulin was regarded as the "input," and the falling glucose concentration as the "output" of the physiological system storing and using glucose. Seven mathematical models of glucose uptake were compared to identify the representation most capable of simulating glucose disappearance. One specific nonlinear model was superior in that it 1) predicted the time course of glucose after glucose injection, 2) had four parameters that could be precisely estimated, and 3) described individual experiments with similar parameter values. Insulin sensitivity index (SI), defined as the dependence of fractional glucose disappearance on plasma insulin, was the ratio of two parameters of the chosen model and could be estimated with good reproducibility from the 300 mg/kg injection experiments (SI = 7.00 X 10(-4) +/- 24% (coefficient of variation) min-1/(microU/ml) (n = 8)). Thus, from a single glucose injection it is possible to obtain a quantitative index of insulin sensitivity that may have clinical applicability.
Roberto Bizzotto
Annotations have not been checked.
This model is not certified.
  • Model owner: Roberto Bizzotto
  • Submitted: Dec 29, 2015 4:11:32 PM
  • Last Modified: May 18, 2016 3:49:43 PM
Revisions
  • Version: 10 public model Download this version
    • Submitted on: May 18, 2016 3:49:43 PM
    • Submitted by: Roberto Bizzotto
    • With comment: Modified accommodations
  • Version: 2 public model Download this version
    • Submitted on: Dec 29, 2015 4:11:32 PM
    • Submitted by: Roberto Bizzotto
    • With comment: Edited model metadata online.
 
Help