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DDMODEL00000104: Time to conversion to sinus rhythm model in acute atrial fibrillation

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Short description:
A model characterizing time to conversion to sinus rhythm under digoxin and placebo in acute atrial fibrillation
Original code
  • Characterizing time to conversion to sinus rhythm under digoxin and placebo in acute atrial fibrillation
  • Stefanie Hennig, Lena E. Friberg, Mats O. Karlsson
  • PAGE-meeing(18), 6/2009
  • Department of Pharmaceutical Bioscience, Uppsala University, Sweden
  • The underlying trial was a randomized, double-blind comparison of intravenously administered digoxin and placebo in patients with acute atrial fibrillation (DAAF). The primary end point was conversion to sinus rhythm within 16 h after randomization, while effect on heart rate (HR) was a secondary end point. The primary publication concluded: “There was no clear correlation between serum concentration of digoxin and changes in ECG or HR”. A later analysis reported on the population pharmacokinetics (PK) of digoxin and a HR model. Here, the aim was to evaluate if any predictor of conversion to sinus rhythm can be found using a Time-to-event (TTE) analysis.
Shijun Wang
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  • Model owner: Shijun Wang
  • Submitted: Dec 11, 2015 2:07:19 PM
  • Last Modified: Jun 3, 2016 11:14:58 AM
Revisions
  • Version: 12 public model Download this version
    • Submitted on: Jun 3, 2016 11:14:58 AM
    • Submitted by: Shijun Wang
    • With comment: Edited model metadata online.
  • Version: 4 public model Download this version
    • Submitted on: Dec 11, 2015 2:07:19 PM
    • Submitted by: Shijun Wang
    • With comment: Edited model metadata online.
 
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