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DDMODEL00000101: Overgaard’s beta cell model for insulin secretion

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Overgaard’s beta cell model for insulin secretion following IVGTT and OGTT
PharmML (0.6.1)
  • Mathematical beta cell model for insulin secretion following IVGTT and OGTT.
  • Overgaard RV, Jelic K, Karlsson M, Henriksen JE, Madsen H
  • Annals of biomedical engineering, 8/2006, Volume 34, Issue 8, pages: 1343-1354
  • Informatics and Mathematical Modelling, Technical University of Denmark, Kongens Lyngby, Denmark. rvo@imm.dtu.dk
  • Evaluation of beta cell function is conducted by a variety of glucose tolerance tests and evaluated by a number of different models with less than perfect consistency among results obtained from different tests. We formulated a new approximation of the distributed threshold model for insulin secretion in order to approach a model for quantifying beta cell function, not only for one, but for several different experiments. Data was obtained from 40 subjects that had both an oral glucose tolerance test (OGTT) and an intravenous tolerance test (IVGTT) performed. Parameter estimates from the two experimental protocols demonstrate similarity, reproducibility, and indications of prognostic relevance. Useful first phase indexes comprise the steady state amount of ready releasable insulin A0 and the rate of redistribution krd, where both yield a considerable correlation (both r=0.67) between IVGTT and OGTT estimates. For the IVGTT, A0 correlates well (r=0.96) with the 10 min area under the curve of insulin above baseline, whereas krd represents a new and possibly more fundamental first phase index. For the useful second phase index gamma, a correlation of 0.75 was found between IVGTT and OGTT estimates.
Roberto Bizzotto
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  • Model owner: Roberto Bizzotto
  • Submitted: Dec 11, 2015 11:53:37 AM
  • Last Modified: Sep 20, 2016 10:21:19 AM
Revisions
  • Version: 11 public model Download this version
    • Submitted on: Sep 20, 2016 10:21:19 AM
    • Submitted by: Roberto Bizzotto
    • With comment: Updated lst file and output plot, produced with Prod4_Beta installation
  • Version: 10 public model Download this version
    • Submitted on: Sep 6, 2016 11:24:41 AM
    • Submitted by: Roberto Bizzotto
    • With comment: Updated Comparison table
  • Version: 9 public model Download this version
    • Submitted on: Sep 6, 2016 10:11:46 AM
    • Submitted by: Roberto Bizzotto
    • With comment: Updated validationOvergaard.R, Comparison_table.pdf and Description_of_simulated_data.pdf
  • Version: 8 public model Download this version
    • Submitted on: Aug 11, 2016 8:54:06 PM
    • Submitted by: Roberto Bizzotto
    • With comment: Updated model annotations.
  • Version: 5 public model Download this version
    • Submitted on: May 18, 2016 3:56:38 PM
    • Submitted by: Roberto Bizzotto
    • With comment: Updated model annotations.
  • Version: 2 public model Download this version
    • Submitted on: Dec 11, 2015 11:53:37 AM
    • Submitted by: Roberto Bizzotto
    • With comment: Edited model metadata online.
 
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